212 has been a big hit in my country already. I agree it's very catchy, and has dance influences, which gives it more crossover appeal.
B.o.B has a lot of very mainstream sounding songs on his album, so maybe one of them could.
Also, another thing worth noting is that now that Billboard include the On-Demand chart in the Hot 100, it boosts basically all the hip hop (and alternative) songs up the chart.
I still think it's very unlikely to happen though. It's weird to see a hip hop song even in the top 10 on iTunes these days.
Well, last year when the chart was filled with Pop candy by Rihanna/Katy/Gaga, hardly anyone believed the two biggest hits of the year would be Alternative. I think, due to Adele, listeners are opening themselves up to different genre's. I agree with 212 though. With the right promotion, it could be a shoo-in for Rap SOTY. The only song B.O.B has is the Taylor collab, who POP hardly play.
I did think a few months ago that Nicki Minaj was one of the only artists who had the potential to do get a hip hop song to #1, but we all know what's happened there....
And the main thing holding Nicki back is her new fans that have suddenly come out of nowhere. She would never be allowed to release a song like Moment 4 Life now. She has to now release constant dance songs as singles or else her new fans give her hell on Twitter about it and complain whenever she suggests promoting an urban song somewhere.
Eminem would probably get a #1, but I don't think he's releasing any new material this year. The artists on Aftermath like to spread all their albums out so they don't take the focus off each other, and I'm pretty sure at least Slaughterhouse and 50 Cent's, and maybe Dr. Dre's, have to come out before Eminem's, so we probably won't get a new album from him until 2013 at the earliest. Maybe his lead single at the end of 2012 if we're lucky.